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The Monarch has filmed a personal message concerning his experience with cancer, which will be broadcast as part of this year's Stand Up To Cancer drive, spearheaded by medical research organisations and a major network.
Official sources confirmed the King would discuss his "recovery journey" as a cancer patient, in a video message on Friday at 8pm UK time.
The address, recorded at his London residence recently, will highlight the critical nature of cancer screening checks to help guarantee more people catch the disease at an treatable phase.
This will be a uncommon insight on the medical condition of the King, who has been in a course of therapy since his condition was announced in early last year. But it is thought improbable the King will identify his particular diagnosis.
The Stand Up To Cancer event each year raises funds for scientific studies and treatment and prompts people to get screenings to boost the odds of an prompt identification.
The King's relative openness about his health challenge, and his experience as a patient, has been aimed to raise awareness and to get more people to get screened - and this will be taken a step further with this unusual personal contribution.
Up until now the King's primary strategy to his cancer has been to keep working, maintaining a busy schedule alongside his ongoing course of care, and he seems not to have wanted to be characterised by his illness.
Recently has seen the King, 77, embarking on several overseas trips, including to Italy and Canada, and hosting the highest tally of foreign dignitaries to the UK for decades, featuring the German president recently.
The upcoming charity show on television, hosted by well-known figures such as several TV personalities, will urge people not to be afraid of getting cancer checks.
The hosts have been affected by cancer - McCall said recently she had had an operation for a tumour, while Clare Balding was overcame a thyroid condition more than 15 years ago. Presenter Hills has previously mentioned his late father, who had one form of cancer and then later leukaemia.
The show will reach out to the approximate 9m people in the UK who charities state are not up to date with national health programmes, with an online checker to let people check if they are qualified for tests for breast, bowel and cervical cancer.
In an attempt to demystify screenings and illustrate the value of timely identification there will be a real-time transmission from cancer clinics at Addenbrooke's and Royal Papworth hospitals in Cambridge.
"My aim is to take the fear from cancer screening and prove all people that they are not isolated in this," said a presenter.
Currently in the UK, there are three national health screening services - for bowel, breast and cervical cancer - offered to specific demographics.
A emerging lung cancer screening programme is also being slowly rolled out for anyone at high risk of being diagnosed with the illness, focusing on people of a certain age, who currently smoke or were former smokers.
Male patients may discuss prostate screenings, but there is lacking a standardised service currently available.
The charity campaign, which has collected a significant sum since 2012, is financing multiple medical projects involving thousands of patients.
King Charles, in a statement for guests at a gathering for cancer charities in the spring, had referred to understanding the "intimidating and at times frightening situation" for cancer sufferers and their families.
But he noted his experience of managing cancer had shown him that "the most difficult times of sickness can be alleviated by the kindness of others," as he commended those who cared for cancer patients.
The Palace has not revealed the specific type of cancer the King has, or the therapies he has been given. The King's cancer was identified after he had received a routine operation.
A seasoned financial analyst and tech enthusiast with over a decade of experience in market strategy and digital transformation.